Hitting GPRC5D made its first splash as part of a preclinical Juno/Celgene Car-T therapy back at Ash 2018, and though it took a long time for this asset to enter the . We've had, for example, a drug with ocular or eye toxicity. Whats really great is that some myeloma cells NOT having BCMA MIGHT have GPRC5D. Effects of teclistamab and talquetamab on soluble BCMA levels in So that would indicate the possibility that GPRC5D could potentially kill myeloma cells left behind after BCMA-based regimens are used! We tried several things. Paul G. Richardson, MD, and Christina Gasparetto, MD, offer insights into the use of proteasome inhibitors in relapsed or refractory multiple myeloma. Nearly 60% had a very good partial response, meaning that their cancer was substantially reduced. Back pain can be a symptom of cancer or a side effect of cancer treatment. But there are six trials recruiting! At the two subcutaneous doses recommended for a phase 2 study (405 g per kilogram weekly [30 patients] and 800 g per kilogram every other week [44 patients]), common adverse events were cytokine release syndrome (in 77% and 80% of the patients, respectively), skin-related events (in 67% and 70%), and dysgeusia (in 63% and 57%); all but one cytokine release syndrome event were of grade 1 or 2. Moreau P, Garfall AL, van de Donk NWCJ, Nahi H, San-Miguel JF, Oriol A, Nooka AK, Martin T, Rosinol L, Chari A, Karlin L, Benboubker L, Mateos MV, Bahlis N, Popat R, Besemer B, Martnez-Lpez J, Sidana S, Delforge M, Pei L, Trancucci D, Verona R, Girgis S, Lin SXW, Olyslager Y, Jaffe M, Uhlar C, Stephenson T, Van Rampelbergh R, Banerjee A, Goldberg JD, Kobos R, Krishnan A, Usmani SZ. . This is a target that is present on plasma cells and has come up as a newer target that can be exploited for disease control. The appearance of Johnson & Johnson's talquetamab in this year's Ash press programme will highlight GPRC5D blockade as an important new mechanism in treating multiple myeloma. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for However, research has not proven these mushrooms can prevent cancer. I tell patients to take a lukewarm or cool shower, [to use] heavy lubricants, body oil, those kinds of thingsbecause the dryness is really severe. Trimm 2 Study - Multiple Myeloma Clinical Trials Accessed August 25, 2022. The median time to a measurable response was approximately 1.2 months in both dosing groups, and the median duration of response is 9.3 months to date with weekly dosing. Just under three-quarters of participants given a lower or higher dose of talquetamab in the Phase 2 portion of J&J's study responded to treatment, with around a third of each group achieving remission of their cancer. In a separate cohort, 51 patients who had previously received therapies that redirect T cells showed a response to talquetamab. Immunotherapy is a type of treatment that affects a person's immune system. Data from patients who had received these same dosing regimens in the first phase were included in the analysis for the second phase. Only one patient to date at our center, has discontinued treatment due to an oral or dermatologic side effect. The new exclusion criteria could represent an incremental headwind for Bluebird should it get to market, wrote SVB Securities analyst Mani Foroohar. Last year at ASH, I studied andlearned more about anew bi-specific antibody drug called talquetamab. Abstract - American Society of Hematology Dose delays may also be an effective method of mitigating oral and dermatologic therapies, she . Talquetamab (JNJ-64407564) is a bispecific IgG4 antibody that redirects T-cell killing to multiple myeloma cells by binding to the novel target, GPRC5D, and CD3. The 73% response rate in this study is higher than that for most currently available therapies. Rich completed his Masters degree in the Arts back in 2013 before joining New Atlas in 2016. "With a median follow-up of 14.9 months (range 0.5+ to 29.0), 74.1 percent of patients treated at the SC [subcutaneous] 0.4 mg/kg dose administered weekly achieved a response, 59.4 percent achieved a very good partial response or better, 33.6 percent achieved a complete response or better and 23.8 percent achieved a stringent complete response," reported pharmaceutical company Johnson & Johnson in a press release. Many of those with a very good partial response had a 90% improvement., He told MNT that phase 3 trials are now underway using a the 2-weekly dosing pattern. These arent people with many options remaining, so in that setting 50% improvement is fantastic, he added. Recent updates on bispecific T-cell engager (BiTE) antibodies in Epcoritamab Shows a Manageable Safety and Robust Antitumour Patients enrolled in MomumenTAL-1 were assigned to a dose level and either the subcutaneous (n = 24; 31.6%) or intravenous (IV) dosing cohort (n = 52; 68.4%). Injection-site reactions were observed in 7.9% of patients. Generic Name. Apalutamide Elicits PSA Response, Lowers Progression to Castration Resistant Disease in mCSPC, Nurse Investigators on Using Weighted Blankets to Alleviate Anxiety During Cancer Treatment Infusions, Best Practices on Managing AEs With Darolutamide Plus ADT/Docetaxel in mHPSC, Jessica MacIntyre on Improving LLS Referrals For Patients With Hematologic Malignancies. Janssen Presents Updated Results Evaluating First-in-Class Talquetamab Talquetamab appears to have a have favorable risk/benefit profile in RRMM with durable responses and manageable toxicities. At the time of data cut-off, 76 patients had been enrolled in the trial at Mount Sinai Hospital. The .gov means its official. The bottom line is that almost 70% of heavily pre-treated triple+ refractory patients responded! And this will us the idea that, for example, if you've had a BCMA-directed CAR T cell, you still could be treated with a bispecific such as talquetamab. Ajai Chari, MD, discusses the safety and efficacy of talquetamab plus daratumumab in heavily pretreated patients with multiple myeloma, initial data from phase 1b TRIMM-2 trial, and the potential . Kerry Boyle D.Ac., M.S., L.Ac., Dipl. . Following treatment with the immunotherapy drug in the Mount Sinai Health System trial, almost three-quarters of the participants showed improvement, with 30% having a complete response to the drug. Theyve exhausted many available therapies []. Myeloma Bispecific Antibody Talquetamab Update - HealthTree for Myeloma They can have a limited impact on quality of life measures.. Kikuchi T, Tsukada N, Nomura M, Kasuya Y, Oda Y, Sato K, Takei T, Ogura M, Abe Y, Suzuki K, Ishida T. Ann Hematol. Is the ketogenic diet right for autoimmune conditions? While that may not sound exciting, it means that much of the preliminary work necessary to prepare for FDA approval is well underway. View duration, location, compensation, and staffing details. 5 months after I stopped, I recovered my sense of taste. Can diet help improve depression symptoms? So those are side effects of both bispecific antibodies and CAR-T cells. FDA Pauses Trial Evaluating MT-0169 in R/R Multiple Myeloma and Lymphoma. Here we report updated results with additional patients (pts) and longer follow-up from MonumenTAL-1, a phase 1 trial of talquetamab in relapsed/refractory multiple myeloma (RRMM). Cancerous plasma cells make abnormal antibodies called M-proteins that do not protect the body from infections. Get the free daily newsletter read by industry experts. sneezing. For example, skin and ear problems, which can sometimes affect patients a little bit differently, but can also be a quality-of-life issue. Were looking at all of that, to try to figure out how to optimize the combination of these drugs in a highly effective regimen, said Tendler. Teclistamab (JNJ-64007957) may be a safe and efficacious treatment option for patients with relapsed/refractory multiple myeloma, according to findings from a phase I study presented at the 2020 American Society of Clinical Oncology . Emerging Strategies to Manage Relapsed and/or Refractory Multiple Myeloma. sore mouth or tongue. Cytokine release syndrome, skin-related events, and dysgeusia were common with talquetamab treatment but were primarily low-grade. Talquetamab for relapsed/refractory multiple myeloma: Results from a Side Effects I've Experienced with Talquetamab - myelomablog In addition to various side effects including Cytokine Release Syndrome (SRS) which are seen in many targeted therapies, Talquetamab causes some "skin related and nail disorder adverse events in 75% of patients" All of the noted side effects, however, were considered manageable and reversible. Talquetamab for Multiple Myeloma Talquetamab, a bifunctional antibody, directs activated T cells to tumor. Talquetamab binds to both T cells and multiple myeloma cells. I am looking forward to seeing how the reduction in frequency of administration will improve the side effects I've been experiencing. It is graphic, but it prepared patients for what to expect.. Nurse Practitioners/Physician's Assistants, 2022 ASCO Genitourinary Cancers Symposium Urothelial Cancer Updates, Contemporary Concepts in Hematologic Oncology, Insights from Experts at Mayo Clinic on Translating Evidence to Clinical Practice, Optimizing Outcomes in Patients with HER2+ Metastatic Breast Cancer, | 2022 ASCO Genitourinary Cancers Symposium Urothelial Cancer Updates, | Contemporary Concepts in Hematologic Oncology, | Insights from Experts at Mayo Clinic on Translating Evidence to Clinical Practice, | Optimizing Outcomes in Patients with HER2+ Metastatic Breast Cancer. DrugBank Accession Number. CB-011, which received fast track designation from the FDA, is currently under investigation as a treatment for those with relapsed or refractory multiple myeloma in the phase 1 CaMMouflage trial. Talquetamab side effects. Characterization and Management of Oral and Dermatological Toxicities I hadn't realized it, but was thinking I had just lost track of when I was getting it. Sequencing is really important, and it's probably the thing that we do the least well in myeloma, he said at the press conference. The Talquetamab / Daratumumab trial. About three-quarters of patients experienced cytokine-release syndrome, 60% experienced skin-related side effects such as rash, about half reported taste changes, and about half reported nail disorders. New blood cancer therapy successful in three-quarters of trial patients, The new treatment is currently under application for review by the FDA. The abnormal plasma cells are made from stem cells in the bone marrow. Talquetamab, a novel CD3 X GPRC5D bispecific antibody, represents a promising therapy for patients with relapsed or refractory multiple myeloma, according to Elizabeth Aronson, MSN, FNP-BCN, OCN. Read on for details and takeaways from the meeting over the weekend: Like many new drug targets, its name is complicated and better off abbreviated. Presented at: European Hematology Association Congress 2022; June 9-12, 2022; Vienna, Austria. In the phase 2 trial, doctors administered all the treatments subcutaneously using doses that had been safe and successful in the phase 1 trial. Teclistamab (Tecvayli) for the Treatment of Multiple Myeloma (Its also found on hairfollicle cells but dont worry youre not going to lose your hair again.) with PDF HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include It also featured important updates on Bluebird bios gene therapy for beta thalassemia and sickle cell disease, data for which have been a conference mainstay for nearly a decade. No unexpected side effects were seen with this association. The response rate observed in the study, which Dr. Chari explained is higher than . One year later, data presented at ASH could help the company make the case for approval in another uncommon autoimmune disease: primary immune thrombocytopenia, or ITP. Children and Cancer . The site is secure. At median follow-ups of 11.7 months (in patients who had received talquetamab at the 405-g dose level) and 4.2 months (in those who had received it at the 800-g dose level), the percentages of patients with a response were 70% (95% confidence interval [CI], 51 to 85) and 64% (95% CI, 48 to 78), respectively. MeSH (Funded by Janssen Research and Development; MonumenTAL-1 ClinicalTrials.gov number, NCT03399799.). Talquetamab induced a substantial response among patients with heavily pretreated relapsed or refractory multiple myeloma. Healthy plasma cells produce antibodies to help people fight disease. Potentially Serious Side Effect Seen in Patient after Immunotherapy In patients with multiple myeloma, GPRC5D is overexpressed and . Recent advances in the treatment of multiple myeloma Researchers are continuing to collect data on the duration of response in the group receiving 0.8 mg/kg every other week and for patients in both dosing groups who had a complete response or better. Study results presented on Saturday and published in The New England Journal of Medicine suggest it could be the next promising drug to emerge in multiple myeloma an area already of intense drugmaker interest. Dima D, Ullah F, Mazzoni S, Williams L, Faiman B, Kurkowski A, Chaulagain C, Raza S, Samaras C, Valent J, Khouri J, Anwer F. Cancers (Basel). Talquetamab is one of several new drugs in the hopper that are giving us triple+ refractory myelomapatients a heart full of hope.
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